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Source document· February 19, 2026

Prothena Reports Fourth Quarter and Full Year 2025 Financial Results, and Provides Financial Guidance and Business Highlights

View original at finance.yahoo.com
Prothena Reports Fourth Quarter and Full Year 2025 Financial Results, and Provides Financial Guidance and Business Highlights Net cash used in operating and investing activities was $23.3 million and $163.7 million for the fourth quarter and full year of 2025, respectively; quarter-end cash and restricted cash position…
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  • Estimated full year 2026 net loss of $67 to $72 million, including estimated $24 million of non-cash share-based compensation expense

    80% confidence

  • Potential to earn up to $105 million in aggregate clinical milestone payments from strategic partners in 2026

    80% confidence

  • PRX012 patients on 400 mg dose for 18 months reached mean centiloid level of ~16.0 CL with 9 of 12 achieving amyloid negativity, but robust plaque clearance was associated with non-competitive rates of ARIA-E

    80% confidence

  • Expect to share more data from preclinical programs later this year (2026)

    80% confidence

  • Prasinezumab has peak sales potential greater than $3.5 billion (unadjusted) and could be the first disease-modifying treatment for Parkinson's disease

    80% confidence

  • Full year 2026 net cash used in operating and investing activities expected to be $50 to $55 million

    80% confidence

  • Partnered programs have the potential to earn up to approximately $3 billion in future aggregate milestones in addition to potential future royalties

    80% confidence

  • Expected to end 2026 with approximately $255 million in cash (midpoint)

    80% confidence
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Q4 2026 Oncology Data Season and Biotech Capital Allocation: ESMO Readouts, Ivonescimab PDUFA, and Diverging Corporate Moves
Late-2026 biotech is driven by a dense catalyst calendar. ESMO 2026 delivers data from ivonescimab, Enhertu, R-DXd and bemarituzumab, and the FDA has set a 14 Nov PDUFA date for the ivonescimab BLA. Capital allocation is diverging. Krystal Biotech authorized a $400M buyback while lowering FY2026 spend guidance and pushing milestones into 2027. Spago is moving to delist from Nasdaq First North. The facts are clinical and corporate events, not AI or fintech, so the finance angle is limited to capital markets (buybacks, guidance, delistings, regulatory timelines).
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EPKINLY Regulatory-Clinical Success Cascade
High probability of expanded label indications, additional combination approvals, and competitive positioning strength in follicular lymphoma market. Predicts positive commercial uptake and potential accelerated review for related indications.
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Where sources disagree
Ford Motor Company
Both facts give cash for Ford Motor Company at the same point in time (2025-12-31; FY 2025 year-end and Q4 2025 year-end are the same date). Both are labelled USD, but the values are 23,356,000,000 and 23.356, which cannot both be true in USD. The two numbers agree once the second is read as billions (23.356 bn = 23,356,000,000), so the economic content is consistent and the conflict is a unit/scale error in the Q4 2025 record. The period is not the reason for the conflict: a Q4 and an FY figure at the same year-end date should match.
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