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Source document· March 16, 2026

Olema Oncology Reports Fourth Quarter and Full Year 2025 Financial and Operating Results

View original at finance.yahoo.com
Olema Oncology Reports Fourth Quarter and Full Year 2025 Financial and Operating Results Olema Oncology On-track to report top-line data in the fall of 2026 from the pivotal Phase 3 OPERA-01 trial of palazestrant as a monotherapy in patients with 2/3L ER+/HER2- metastatic breast cancer Advanced enrollment in the OPERA-…
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  • Palazestrant has potential as the combination endocrine therapy of choice in the metastatic setting

    60% confidence

  • Commercial launch preparations are underway for a potential approval in late 2027

    60% confidence

  • Transformation into a fully-integrated oncology company is underway in preparation for the Company's first potential commercial launch in late 2027

    60% confidence

  • Top-line data from OPERA-01 is expected in the fall of 2026

    60% confidence

  • The November 2025 public offering enables funding operations through numerous expected value-creating events with palazestrant

    60% confidence

  • Olema is on-track to report top-line data in the fall of 2026 from the pivotal Phase 3 OPERA-01 trial

    60% confidence

  • Initial clinical results from OP-3136 are anticipated in Q2 2026

    60% confidence

  • 2025 was a year of strong execution across the business as we advanced palazestrant as a differentiated endocrine therapy across multiple regimens

    60% confidence
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A wave of vertical AI-agent startups (Swarm, Veridox, Avallon AI, DA2, F2, Earthian, Meanwhile, Covecta, Penguin AI, Maisa AI) is being funded and profiled just as major infrastructure players — Microsoft/Mistral, Siemens/NVIDIA, and Manulife/Microsoft — cement enterprise AI governance and compute partnerships. Yet a Google Cloud report shows AI agents still lack access to the majority of company data (only 45% on average), and insider selling at incumbent C3.ai signals investor caution even as adoption intent (100% planned agentic AI use within two years) races ahead of actual data infrastructure.
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Berkshire Hathaway
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